Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease

TCR signal attenuation selectively favors Foxp3 expression and T reg cell lineage commitment.

Bibliographic Details
Main Authors: Hwang, SuJin, Song, Ki-Duk, Lesourne, Renaud, Lee, Jan, Pinkhasov, Julia, Li, LiQi, El-Khoury, Dalal, Love, Paul E.
Format: Online
Language:English
Published: The Rockefeller University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457736/