Thunderclap headache without hypertension in a patient with pheochromocytoma

Pheochromocytoma is a well known, catecholamine-producing tumor characterized by hypertension, headache, hyperglycemia, hypermetabolism, and hyperhydrosis. Approximately 65% of cases of pheochromocytoma were shown to be associated with hypertension. A case of pheochromocytoma that presented with thu...

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Main Authors:	Watanabe, Masahiko, Takahashi, Akimitsu, Shimano, Hitoshi, Hara, Hisato, Sugita, Shintaro, Nakamagoe, Kiyotaka, Tamaoka, Akira
Format:	Online
Language:	English
Published:	Springer Milan 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452279/

id	pubmed-3452279
recordtype	oai_dc
spelling	pubmed-34522792012-11-29 Thunderclap headache without hypertension in a patient with pheochromocytoma Watanabe, Masahiko Takahashi, Akimitsu Shimano, Hitoshi Hara, Hisato Sugita, Shintaro Nakamagoe, Kiyotaka Tamaoka, Akira Brief Report Pheochromocytoma is a well known, catecholamine-producing tumor characterized by hypertension, headache, hyperglycemia, hypermetabolism, and hyperhydrosis. Approximately 65% of cases of pheochromocytoma were shown to be associated with hypertension. A case of pheochromocytoma that presented with thunderclap headache (TCH) and palpitations is reported. The patient never showed hypertension during the course of the disease. Paroxysmal headache and palpitations led to the identification of the underlying condition, and the final diagnosis was confirmed by histopathological examination of a surgical specimen. Pheochromocytoma should be identified as a less common although important cause of TCH. In addition, due to its lack of utility in identifying this disorder, negative cranial imaging may impede further investigation of extracranial lesions that may be the cause of a patient’s headache. According to the International Classification of Headache Disorders (ICHD)-II, headache attributed to pheochromocytoma usually develops concomitantly with an abrupt increase in blood pressure. In our case, however, hypertension was never observed, even when the patient was symptomatic. This is the first report of a case of pheochromocytoma with TCH without hypertension. Springer Milan 2010-07-13 2010-10 /pmc/articles/PMC3452279/ /pubmed/20625917 http://dx.doi.org/10.1007/s10194-010-0234-z Text en © Springer-Verlag 2010
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Watanabe, Masahiko Takahashi, Akimitsu Shimano, Hitoshi Hara, Hisato Sugita, Shintaro Nakamagoe, Kiyotaka Tamaoka, Akira
spellingShingle	Watanabe, Masahiko Takahashi, Akimitsu Shimano, Hitoshi Hara, Hisato Sugita, Shintaro Nakamagoe, Kiyotaka Tamaoka, Akira Thunderclap headache without hypertension in a patient with pheochromocytoma
author_facet	Watanabe, Masahiko Takahashi, Akimitsu Shimano, Hitoshi Hara, Hisato Sugita, Shintaro Nakamagoe, Kiyotaka Tamaoka, Akira
author_sort	Watanabe, Masahiko
title	Thunderclap headache without hypertension in a patient with pheochromocytoma
title_short	Thunderclap headache without hypertension in a patient with pheochromocytoma
title_full	Thunderclap headache without hypertension in a patient with pheochromocytoma
title_fullStr	Thunderclap headache without hypertension in a patient with pheochromocytoma
title_full_unstemmed	Thunderclap headache without hypertension in a patient with pheochromocytoma
title_sort	thunderclap headache without hypertension in a patient with pheochromocytoma
description	Pheochromocytoma is a well known, catecholamine-producing tumor characterized by hypertension, headache, hyperglycemia, hypermetabolism, and hyperhydrosis. Approximately 65% of cases of pheochromocytoma were shown to be associated with hypertension. A case of pheochromocytoma that presented with thunderclap headache (TCH) and palpitations is reported. The patient never showed hypertension during the course of the disease. Paroxysmal headache and palpitations led to the identification of the underlying condition, and the final diagnosis was confirmed by histopathological examination of a surgical specimen. Pheochromocytoma should be identified as a less common although important cause of TCH. In addition, due to its lack of utility in identifying this disorder, negative cranial imaging may impede further investigation of extracranial lesions that may be the cause of a patient’s headache. According to the International Classification of Headache Disorders (ICHD)-II, headache attributed to pheochromocytoma usually develops concomitantly with an abrupt increase in blood pressure. In our case, however, hypertension was never observed, even when the patient was symptomatic. This is the first report of a case of pheochromocytoma with TCH without hypertension.
publisher	Springer Milan
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452279/
_version_	1611911391328862208

Thunderclap headache without hypertension in a patient with pheochromocytoma

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