Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia

Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia

Objective: We aim to evaluate the effectiveness of the brush biopsy technique using OralCDx ® (OralScan Laboratories Inc., Suffern, NY) as a new method for early diagnosis and control of a “potentially malignant disorder” such as oral leukoplakia. Design of the study: We performed a study in which s...

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Main Authors: Seijas-Naya, Flavio, García-Carnicero, Tamara, Gándara-Vila, Pilar, Couso-Folgueiras, Elena, Pérez-Sayáns, Mario, Gándara-Vila, Rafael, García-García, Abel, Gándara-Rey, José-Manuel
Format: Online
Language:English
Published: Medicina Oral S.L. 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448203/
id pubmed-3448203
recordtype oai_dc
spelling pubmed-34482032012-10-11 Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia Seijas-Naya, Flavio García-Carnicero, Tamara Gándara-Vila, Pilar Couso-Folgueiras, Elena Pérez-Sayáns, Mario Gándara-Vila, Rafael García-García, Abel Gándara-Rey, José-Manuel Research-Article Objective: We aim to evaluate the effectiveness of the brush biopsy technique using OralCDx ® (OralScan Laboratories Inc., Suffern, NY) as a new method for early diagnosis and control of a “potentially malignant disorder” such as oral leukoplakia. Design of the study: We performed a study in which samples were taken using OralCDx ® on 24 patients who visited the Master of Oral Medicine, Oral Surgery and Implantology of the University of Santiago de Compostela between February 2009 and May 2010. These patients presented clinical and histological lesions that were consistent with oral leukoplakia. We evaluated the relationship between the keratinization degree of the lesions and cell representation; the diagnosis obtained through OralCDx ® and biopsies; and sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Results: 50% of patients were men and 50% women with an average age of 62.38 years. The Kappa coefficient relating keratinization of lesions and cell representation was 0.33, the OralCDx ® - biopsy diagnostic rate reached a Kappa value of 0.66, recording 72.7%,sensitivity and 92.3% specificity, PPV was 88.8%, while NPV reached 80%. Conclusions: cytology sampling with OralCDx ® showed high sensitivity and specificity values, which make it a good tool for monitoring oral leukoplakia, but nowadays the most reliable method that allows us to confirm the exact diagnosis of the lesions and their anatomical and pathological characteristics still is conventional biopsy using a surgical scalpel. Medicina Oral S.L. 2012-01 2011-07-15 /pmc/articles/PMC3448203/ /pubmed/21743402 http://dx.doi.org/10.4317/medoral.17275 Text en Copyright: © 2012 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Seijas-Naya, Flavio
García-Carnicero, Tamara
Gándara-Vila, Pilar
Couso-Folgueiras, Elena
Pérez-Sayáns, Mario
Gándara-Vila, Rafael
García-García, Abel
Gándara-Rey, José-Manuel
spellingShingle Seijas-Naya, Flavio
García-Carnicero, Tamara
Gándara-Vila, Pilar
Couso-Folgueiras, Elena
Pérez-Sayáns, Mario
Gándara-Vila, Rafael
García-García, Abel
Gándara-Rey, José-Manuel
Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia
author_facet Seijas-Naya, Flavio
García-Carnicero, Tamara
Gándara-Vila, Pilar
Couso-Folgueiras, Elena
Pérez-Sayáns, Mario
Gándara-Vila, Rafael
García-García, Abel
Gándara-Rey, José-Manuel
author_sort Seijas-Naya, Flavio
title Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia
title_short Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia
title_full Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia
title_fullStr Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia
title_full_unstemmed Applications of OralCDx ® methodology in the diagnosis of oral leukoplakia
title_sort applications of oralcdx ® methodology in the diagnosis of oral leukoplakia
description Objective: We aim to evaluate the effectiveness of the brush biopsy technique using OralCDx ® (OralScan Laboratories Inc., Suffern, NY) as a new method for early diagnosis and control of a “potentially malignant disorder” such as oral leukoplakia. Design of the study: We performed a study in which samples were taken using OralCDx ® on 24 patients who visited the Master of Oral Medicine, Oral Surgery and Implantology of the University of Santiago de Compostela between February 2009 and May 2010. These patients presented clinical and histological lesions that were consistent with oral leukoplakia. We evaluated the relationship between the keratinization degree of the lesions and cell representation; the diagnosis obtained through OralCDx ® and biopsies; and sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Results: 50% of patients were men and 50% women with an average age of 62.38 years. The Kappa coefficient relating keratinization of lesions and cell representation was 0.33, the OralCDx ® - biopsy diagnostic rate reached a Kappa value of 0.66, recording 72.7%,sensitivity and 92.3% specificity, PPV was 88.8%, while NPV reached 80%. Conclusions: cytology sampling with OralCDx ® showed high sensitivity and specificity values, which make it a good tool for monitoring oral leukoplakia, but nowadays the most reliable method that allows us to confirm the exact diagnosis of the lesions and their anatomical and pathological characteristics still is conventional biopsy using a surgical scalpel.
publisher Medicina Oral S.L.
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448203/
_version_ 1611910840803393536

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