Dynamic diffuse optical tomography imaging of peripheral arterial disease
Peripheral arterial disease (PAD) is the narrowing of arteries due to plaque accumulation in the vascular walls. This leads to insufficient blood supply to the extremities and can ultimately cause cell death. Currently available methods are ineffective in diagnosing PAD in patients with calcified ar...
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| Format: | Online |
| Language: | English |
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Optical Society of America
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447568/ |
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pubmed-3447568 |
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pubmed-34475682012-09-28 Dynamic diffuse optical tomography imaging of peripheral arterial disease Khalil, Michael A. Kim, Hyun K. Kim, In-Kyong Flexman, Molly Dayal, Rajeev Shrikhande, Gautam Hielscher, Andreas H. Diffuse Optical Imaging Peripheral arterial disease (PAD) is the narrowing of arteries due to plaque accumulation in the vascular walls. This leads to insufficient blood supply to the extremities and can ultimately cause cell death. Currently available methods are ineffective in diagnosing PAD in patients with calcified arteries, such as those with diabetes. In this paper we investigate the potential of dynamic diffuse optical tomography (DDOT) as an alternative way to assess PAD in the lower extremities. DDOT is a non-invasive, non-ionizing imaging modality that uses near-infrared light to create spatio-temporal maps of oxy- and deoxy-hemoglobin in tissue. We present three case studies in which we used DDOT to visualize vascular perfusion of a healthy volunteer, a PAD patient and a diabetic PAD patient with calcified arteries. These preliminary results show significant differences in DDOT time-traces and images between all three cases, underscoring the potential of DDOT as a new diagnostic tool. Optical Society of America 2012-08-30 /pmc/articles/PMC3447568/ /pubmed/23024920 http://dx.doi.org/10.1364/BOE.3.002288 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Khalil, Michael A. Kim, Hyun K. Kim, In-Kyong Flexman, Molly Dayal, Rajeev Shrikhande, Gautam Hielscher, Andreas H. |
| spellingShingle |
Khalil, Michael A. Kim, Hyun K. Kim, In-Kyong Flexman, Molly Dayal, Rajeev Shrikhande, Gautam Hielscher, Andreas H. Dynamic diffuse optical tomography imaging of peripheral arterial disease |
| author_facet |
Khalil, Michael A. Kim, Hyun K. Kim, In-Kyong Flexman, Molly Dayal, Rajeev Shrikhande, Gautam Hielscher, Andreas H. |
| author_sort |
Khalil, Michael A. |
| title |
Dynamic diffuse optical tomography imaging of peripheral arterial disease |
| title_short |
Dynamic diffuse optical tomography imaging of peripheral arterial disease |
| title_full |
Dynamic diffuse optical tomography imaging of peripheral arterial disease |
| title_fullStr |
Dynamic diffuse optical tomography imaging of peripheral arterial disease |
| title_full_unstemmed |
Dynamic diffuse optical tomography imaging of peripheral arterial disease |
| title_sort |
dynamic diffuse optical tomography imaging of peripheral arterial disease |
| description |
Peripheral arterial disease (PAD) is the narrowing of arteries due to plaque accumulation in the vascular walls. This leads to insufficient blood supply to the extremities and can ultimately cause cell death. Currently available methods are ineffective in diagnosing PAD in patients with calcified arteries, such as those with diabetes. In this paper we investigate the potential of dynamic diffuse optical tomography (DDOT) as an alternative way to assess PAD in the lower extremities. DDOT is a non-invasive, non-ionizing imaging modality that uses near-infrared light to create spatio-temporal maps of oxy- and deoxy-hemoglobin in tissue. We present three case studies in which we used DDOT to visualize vascular perfusion of a healthy volunteer, a PAD patient and a diabetic PAD patient with calcified arteries. These preliminary results show significant differences in DDOT time-traces and images between all three cases, underscoring the potential of DDOT as a new diagnostic tool. |
| publisher |
Optical Society of America |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447568/ |
| _version_ |
1611910520223301632 |