Selection and inhibition mechanisms for human voluntary action decisions
One can choose between action alternatives that have no apparent difference in their outcomes. Such voluntary action decisions are associated with widespread frontal–parietal activation, and a tendency to inhibit the repetition of a previous action. However, the mechanism of initiating voluntary act...
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| Format: | Online |
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Academic Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445813/ |
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pubmed-34458132012-10-15 Selection and inhibition mechanisms for human voluntary action decisions Zhang, Jiaxiang Hughes, Laura E. Rowe, James B. Article One can choose between action alternatives that have no apparent difference in their outcomes. Such voluntary action decisions are associated with widespread frontal–parietal activation, and a tendency to inhibit the repetition of a previous action. However, the mechanism of initiating voluntary actions and the functions of different brain regions during this process remains largely unknown. Here, we combine computational modeling and functional magnetic resonance imaging to test the selection and inhibition mechanisms that mediate trial-to-trial voluntary action decisions. We fitted an optimized accumulator model to behavioral responses in a finger-tapping task in which participants were instructed to make chosen actions or specified actions. Model parameters derived from each individual were then applied to estimate the expected accumulated metabolic activity (EAA) engaged in every single trial. The EAA was associated with blood oxygenation level-dependent responses in a decision work that was maximal in the supplementary motor area and the caudal anterior cingulate cortex, consistent with a competitive accumulation-to-threshold mechanism for action decision by these regions. Furthermore, specific inhibition of the previous action's accumulator was related to the suppression of response repetition. This action-specific inhibition correlated with the activity of the right inferior frontal gyrus, when the option to repeat existed. Our findings suggest that human voluntary action decisions are mediated by complementary processes of intentional selection and inhibition. Academic Press 2012-10-15 /pmc/articles/PMC3445813/ /pubmed/22776456 http://dx.doi.org/10.1016/j.neuroimage.2012.06.058 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhang, Jiaxiang Hughes, Laura E. Rowe, James B. |
| spellingShingle |
Zhang, Jiaxiang Hughes, Laura E. Rowe, James B. Selection and inhibition mechanisms for human voluntary action decisions |
| author_facet |
Zhang, Jiaxiang Hughes, Laura E. Rowe, James B. |
| author_sort |
Zhang, Jiaxiang |
| title |
Selection and inhibition mechanisms for human voluntary action decisions |
| title_short |
Selection and inhibition mechanisms for human voluntary action decisions |
| title_full |
Selection and inhibition mechanisms for human voluntary action decisions |
| title_fullStr |
Selection and inhibition mechanisms for human voluntary action decisions |
| title_full_unstemmed |
Selection and inhibition mechanisms for human voluntary action decisions |
| title_sort |
selection and inhibition mechanisms for human voluntary action decisions |
| description |
One can choose between action alternatives that have no apparent difference in their outcomes. Such voluntary action decisions are associated with widespread frontal–parietal activation, and a tendency to inhibit the repetition of a previous action. However, the mechanism of initiating voluntary actions and the functions of different brain regions during this process remains largely unknown. Here, we combine computational modeling and functional magnetic resonance imaging to test the selection and inhibition mechanisms that mediate trial-to-trial voluntary action decisions. We fitted an optimized accumulator model to behavioral responses in a finger-tapping task in which participants were instructed to make chosen actions or specified actions. Model parameters derived from each individual were then applied to estimate the expected accumulated metabolic activity (EAA) engaged in every single trial. The EAA was associated with blood oxygenation level-dependent responses in a decision work that was maximal in the supplementary motor area and the caudal anterior cingulate cortex, consistent with a competitive accumulation-to-threshold mechanism for action decision by these regions. Furthermore, specific inhibition of the previous action's accumulator was related to the suppression of response repetition. This action-specific inhibition correlated with the activity of the right inferior frontal gyrus, when the option to repeat existed. Our findings suggest that human voluntary action decisions are mediated by complementary processes of intentional selection and inhibition. |
| publisher |
Academic Press |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445813/ |
| _version_ |
1611909916101967872 |