A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors

A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors

Transgenic expression of the MafB oncogene in haematopoietic stem/progenitor cells induces plasma cell neoplasia reminiscent of human multiple myeloma and suggests DNA methylation as cause of malignant transformation.

Bibliographic Details
Main Authors: Vicente-Dueñas, Carolina, Romero-Camarero, Isabel, González-Herrero, Inés, Alonso-Escudero, Esther, Abollo-Jiménez, Fernando, Jiang, Xiaoyu, Gutierrez, Norma C, Orfao, Alberto, Marín, Nieves, Villar, Luisa María, Criado, Ma Carmen Fernández, Pintado, Belén, Flores, Teresa, Alonso-López, Diego, De Las Rivas, Javier, Jiménez, Rafael, Criado, Francisco Javier García, Cenador, María Begoña García, Lossos, Izidore S, Cobaleda, César, Sánchez-García, Isidro
Format: Online
Language:English
Published: Nature Publishing Group 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442275/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442275/

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