Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking

Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking

Most cystic fibrosis is caused by mutations in CFTR that prevent its trafficking from the ER to the plasma membrane and is associated with exaggerated inflammation, altered metabolism, and diminished responses to oxidative stress. PARP-1 is activated by oxidative stress and causes energy depletion a...

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Bibliographic Details
Main Authors: Anjos, Suzana M., Robert, Renaud, Waller, Daniel, Zhang, Dong Lei, Balghi, Haouaria, Sampson, Heidi M., Ciciriello, Fabiana, Lesimple, Pierre, Carlile, Graeme W., Goepp, Julie, Liao, Jie, Ferraro, Pasquale, Phillipe, Romeo, Dantzer, Françoise, Hanrahan, John W., Thomas, David Y.
Format: Online
Language:English
Published: Frontiers Research Foundation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439826/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439826/

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