Roles of microRNAs in atherosclerosis and restenosis
Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly performed in patients with atherosclerotic disease. However, the restenosis usually has a...
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BioMed Central
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438039/ |
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pubmed-34380392012-09-11 Roles of microRNAs in atherosclerosis and restenosis Chen, Li-Jing Lim, Seh Hong Yeh, Yi-Ting Lien, Sheng-Chieh Chiu, Jeng-Jiann Review Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly performed in patients with atherosclerotic disease. However, the restenosis usually has a high incidence rate in angioplasty patients. Although the pathophysiological mechanisms underlying atherosclerosis and restenosis have been well established, new signaling molecules that control the progress of these pathologies have continuously been discovered. MicroRNAs (miRs) have recently emerged as a novel class of gene regulators that work via transcriptional degradation and translational inhibition or activation. Over 30% of genes in the cell can be directly regulated by miRs. Thus, miRs are recognized as crucial regulators in normal development, physiology and pathogenesis. AIterations of miR expression profiles have been revealed in diverse vascular diseases. A variety of functions of vascular cells, such as cell differentiation, contraction, migration, proliferation and inflammation that are involved in angiogenesis, neointimal formation and lipid metabolism underlying various vascular diseases, have been found to be regulated by miRs. This review summarizes current research progress and knowledge on the roles of miRs in regulating vascular cell function in atherosclerosis and restenosis. These discoveries are expected to present opportunities for clinical diagnostic and therapeutic approaches in vascular diseases resulting from atherosclerosis and restenosis. BioMed Central 2012-08-29 /pmc/articles/PMC3438039/ /pubmed/22931291 http://dx.doi.org/10.1186/1423-0127-19-79 Text en Copyright ©2012 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chen, Li-Jing Lim, Seh Hong Yeh, Yi-Ting Lien, Sheng-Chieh Chiu, Jeng-Jiann |
| spellingShingle |
Chen, Li-Jing Lim, Seh Hong Yeh, Yi-Ting Lien, Sheng-Chieh Chiu, Jeng-Jiann Roles of microRNAs in atherosclerosis and restenosis |
| author_facet |
Chen, Li-Jing Lim, Seh Hong Yeh, Yi-Ting Lien, Sheng-Chieh Chiu, Jeng-Jiann |
| author_sort |
Chen, Li-Jing |
| title |
Roles of microRNAs in atherosclerosis and restenosis |
| title_short |
Roles of microRNAs in atherosclerosis and restenosis |
| title_full |
Roles of microRNAs in atherosclerosis and restenosis |
| title_fullStr |
Roles of microRNAs in atherosclerosis and restenosis |
| title_full_unstemmed |
Roles of microRNAs in atherosclerosis and restenosis |
| title_sort |
roles of micrornas in atherosclerosis and restenosis |
| description |
Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly performed in patients with atherosclerotic disease. However, the restenosis usually has a high incidence rate in angioplasty patients. Although the pathophysiological mechanisms underlying atherosclerosis and restenosis have been well established, new signaling molecules that control the progress of these pathologies have continuously been discovered. MicroRNAs (miRs) have recently emerged as a novel class of gene regulators that work via transcriptional degradation and translational inhibition or activation. Over 30% of genes in the cell can be directly regulated by miRs. Thus, miRs are recognized as crucial regulators in normal development, physiology and pathogenesis. AIterations of miR expression profiles have been revealed in diverse vascular diseases. A variety of functions of vascular cells, such as cell differentiation, contraction, migration, proliferation and inflammation that are involved in angiogenesis, neointimal formation and lipid metabolism underlying various vascular diseases, have been found to be regulated by miRs. This review summarizes current research progress and knowledge on the roles of miRs in regulating vascular cell function in atherosclerosis and restenosis. These discoveries are expected to present opportunities for clinical diagnostic and therapeutic approaches in vascular diseases resulting from atherosclerosis and restenosis. |
| publisher |
BioMed Central |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438039/ |
| _version_ |
1611555483276017664 |