Neurological perspectives on voltage-gated sodium channels

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as m...

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Main Authors:	Eijkelkamp, Niels, Linley, John E., Baker, Mark D., Minett, Michael S., Cregg, Roman, Werdehausen, Robert, Rugiero, François, Wood, John N.
Format:	Online
Language:	English
Published:	Oxford University Press 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437034/

id	pubmed-3437034
recordtype	oai_dc
spelling	pubmed-34370342012-09-10 Neurological perspectives on voltage-gated sodium channels Eijkelkamp, Niels Linley, John E. Baker, Mark D. Minett, Michael S. Cregg, Roman Werdehausen, Robert Rugiero, François Wood, John N. Review Article The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors. Oxford University Press 2012-09 2012-08-29 /pmc/articles/PMC3437034/ /pubmed/22961543 http://dx.doi.org/10.1093/brain/aws225 Text en © The Author 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Eijkelkamp, Niels Linley, John E. Baker, Mark D. Minett, Michael S. Cregg, Roman Werdehausen, Robert Rugiero, François Wood, John N.
spellingShingle	Eijkelkamp, Niels Linley, John E. Baker, Mark D. Minett, Michael S. Cregg, Roman Werdehausen, Robert Rugiero, François Wood, John N. Neurological perspectives on voltage-gated sodium channels
author_facet	Eijkelkamp, Niels Linley, John E. Baker, Mark D. Minett, Michael S. Cregg, Roman Werdehausen, Robert Rugiero, François Wood, John N.
author_sort	Eijkelkamp, Niels
title	Neurological perspectives on voltage-gated sodium channels
title_short	Neurological perspectives on voltage-gated sodium channels
title_full	Neurological perspectives on voltage-gated sodium channels
title_fullStr	Neurological perspectives on voltage-gated sodium channels
title_full_unstemmed	Neurological perspectives on voltage-gated sodium channels
title_sort	neurological perspectives on voltage-gated sodium channels
description	The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.
publisher	Oxford University Press
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437034/
_version_	1611555145338847232

Neurological perspectives on voltage-gated sodium channels

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