Exploiting multimode waveguides for pure fibre-based imaging
There has been an immense drive in modern microscopy towards miniaturization and fibre-based technology. This has been necessitated by the need to access hostile or difficult environments in situ and in vivo. Strategies to date have included the use of specialist fibres and miniaturized scanning sys...
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| Format: | Online |
| Language: | English |
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Nature Pub. Group
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432471/ |
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pubmed-3432471 |
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pubmed-34324712012-09-05 Exploiting multimode waveguides for pure fibre-based imaging Čižmár, Tomáš Dholakia, Kishan Article There has been an immense drive in modern microscopy towards miniaturization and fibre-based technology. This has been necessitated by the need to access hostile or difficult environments in situ and in vivo. Strategies to date have included the use of specialist fibres and miniaturized scanning systems accompanied by ingenious microfabricated lenses. Here we present a novel approach for this field by utilizing disordered light within a standard multimode optical fibre for lensless microscopy and optical mode conversion. We demonstrate the modalities of bright- and dark-field imaging and scanning fluorescence microscopy at acquisition rates that allow observation of dynamic processes such as Brownian motion of mesoscopic particles. Furthermore, we show how such control can realize a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices. These may be useful for future fibre-based implementations of super-resolution or light-sheet microscopy. Nature Pub. Group 2012-08-28 /pmc/articles/PMC3432471/ /pubmed/22929784 http://dx.doi.org/10.1038/ncomms2024 Text en Copyright © 2012, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Čižmár, Tomáš Dholakia, Kishan |
| spellingShingle |
Čižmár, Tomáš Dholakia, Kishan Exploiting multimode waveguides for pure fibre-based imaging |
| author_facet |
Čižmár, Tomáš Dholakia, Kishan |
| author_sort |
Čižmár, Tomáš |
| title |
Exploiting multimode waveguides for pure fibre-based imaging |
| title_short |
Exploiting multimode waveguides for pure fibre-based imaging |
| title_full |
Exploiting multimode waveguides for pure fibre-based imaging |
| title_fullStr |
Exploiting multimode waveguides for pure fibre-based imaging |
| title_full_unstemmed |
Exploiting multimode waveguides for pure fibre-based imaging |
| title_sort |
exploiting multimode waveguides for pure fibre-based imaging |
| description |
There has been an immense drive in modern microscopy towards miniaturization and fibre-based technology. This has been necessitated by the need to access hostile or difficult environments in situ and in vivo. Strategies to date have included the use of specialist fibres and miniaturized scanning systems accompanied by ingenious microfabricated lenses. Here we present a novel approach for this field by utilizing disordered light within a standard multimode optical fibre for lensless microscopy and optical mode conversion. We demonstrate the modalities of bright- and dark-field imaging and scanning fluorescence microscopy at acquisition rates that allow observation of dynamic processes such as Brownian motion of mesoscopic particles. Furthermore, we show how such control can realize a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices. These may be useful for future fibre-based implementations of super-resolution or light-sheet microscopy. |
| publisher |
Nature Pub. Group |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432471/ |
| _version_ |
1611553780201947136 |