Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power
Toxicokinetic-toxicodynamic (TKTD) models quantify the time-course of internal concentration, which is defined by uptake, elimination and biotransformation (TK), and the processes which lead to the toxic effects (TD). TKTD models show potential in predicting pesticide effects in fluctuating concentr...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer US
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431474/ |