Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+ dendritic cells
PolyI:C is a nucleotide pattern molecule that induces cross-presentation of foreign Ag in myeloid dendritic cells (DC) and MHC Class I-dependent proliferation of cytotoxic T lymphocytes (CTL). DC (BM or spleen CD8α+) have sensors for dsRNA including polyI:C to signal facilitating cross-presentation....
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Landes Bioscience
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429562/ |