Regulators of epithelial mesenchymal transition in pancreatic cancer

Pancreatic cancer is a leading cause of cancer-related death due to its invasive nature. Despite the improvement of diagnostic strategy, early diagnosis of pancreatic cancer is still challenging. Surgical resection is the only curative therapy, while vast majority of patients are not eligible for th...

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Main Authors:	Hamada, Shin, Satoh, Kennichi, Masamune, Atsushi, Shimosegawa, Tooru
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429031/

id	pubmed-3429031
recordtype	oai_dc
spelling	pubmed-34290312012-08-29 Regulators of epithelial mesenchymal transition in pancreatic cancer Hamada, Shin Satoh, Kennichi Masamune, Atsushi Shimosegawa, Tooru Physiology Pancreatic cancer is a leading cause of cancer-related death due to its invasive nature. Despite the improvement of diagnostic strategy, early diagnosis of pancreatic cancer is still challenging. Surgical resection is the only curative therapy, while vast majority of patients are not eligible for this therapeutic option. Complex biological processes are involved in the establishment of invasion and metastasis of pancreatic cancer and epithelial-mesenchymal transition (EMT) has been reported to play crucial role. EMT is part of the normal developmental processes which mobilizes epithelial cells and yields mesenchymal phenotype. Deregulation of EMT inducing molecules in pancreatic cancer is reported, such as multiple cytokines, growth factors and downstream transcriptional factors. In addition to these molecules, non-coding RNA including miRNA also contributes to EMT. EMT of cancer cell also correlates with cancer stem cell (CSC) properties such as chemoresistance or tumorigenicity, therefore these upstream regulators of EMT could be attractive therapeutic targets and several candidates are examined for clinical application. This review summarizes recent advances in this field, focusing the regulatory molecules of EMT and their downstream targets. Further understanding and research advances will clarify the cryptic mechanism of cancer metastasis and delineate novel therapeutic targets. Frontiers Media S.A. 2012-07-10 /pmc/articles/PMC3429031/ /pubmed/22934011 http://dx.doi.org/10.3389/fphys.2012.00254 Text en Copyright © 2012 Hamada, Satoh, Masamune and Shimosegawa. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hamada, Shin Satoh, Kennichi Masamune, Atsushi Shimosegawa, Tooru
spellingShingle	Hamada, Shin Satoh, Kennichi Masamune, Atsushi Shimosegawa, Tooru Regulators of epithelial mesenchymal transition in pancreatic cancer
author_facet	Hamada, Shin Satoh, Kennichi Masamune, Atsushi Shimosegawa, Tooru
author_sort	Hamada, Shin
title	Regulators of epithelial mesenchymal transition in pancreatic cancer
title_short	Regulators of epithelial mesenchymal transition in pancreatic cancer
title_full	Regulators of epithelial mesenchymal transition in pancreatic cancer
title_fullStr	Regulators of epithelial mesenchymal transition in pancreatic cancer
title_full_unstemmed	Regulators of epithelial mesenchymal transition in pancreatic cancer
title_sort	regulators of epithelial mesenchymal transition in pancreatic cancer
description	Pancreatic cancer is a leading cause of cancer-related death due to its invasive nature. Despite the improvement of diagnostic strategy, early diagnosis of pancreatic cancer is still challenging. Surgical resection is the only curative therapy, while vast majority of patients are not eligible for this therapeutic option. Complex biological processes are involved in the establishment of invasion and metastasis of pancreatic cancer and epithelial-mesenchymal transition (EMT) has been reported to play crucial role. EMT is part of the normal developmental processes which mobilizes epithelial cells and yields mesenchymal phenotype. Deregulation of EMT inducing molecules in pancreatic cancer is reported, such as multiple cytokines, growth factors and downstream transcriptional factors. In addition to these molecules, non-coding RNA including miRNA also contributes to EMT. EMT of cancer cell also correlates with cancer stem cell (CSC) properties such as chemoresistance or tumorigenicity, therefore these upstream regulators of EMT could be attractive therapeutic targets and several candidates are examined for clinical application. This review summarizes recent advances in this field, focusing the regulatory molecules of EMT and their downstream targets. Further understanding and research advances will clarify the cryptic mechanism of cancer metastasis and delineate novel therapeutic targets.
publisher	Frontiers Media S.A.
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429031/
_version_	1611552564362346496

Regulators of epithelial mesenchymal transition in pancreatic cancer

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