Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma

Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma

Paraneoplastic cerebellar degeneration (PCD) is a rare disorder presenting typically with acute or subacute severe cerebellar ataxia. PCD is most commonly associated with small cell lung cancer followed by adenocarcinoma of breast and ovary, and Hogdkin's lymphoma. We report a case of a 54-year...

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Main Authors: Suri, Vinit, Khan, Nadeem I., Jadhao, Nilesh, Gupta, Rohan
Format: Online
Language:English
Published: Medknow Publications & Media Pvt Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424800/
id pubmed-3424800
recordtype oai_dc
spelling pubmed-34248002012-08-23 Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma Suri, Vinit Khan, Nadeem I. Jadhao, Nilesh Gupta, Rohan Case Report Paraneoplastic cerebellar degeneration (PCD) is a rare disorder presenting typically with acute or subacute severe cerebellar ataxia. PCD is most commonly associated with small cell lung cancer followed by adenocarcinoma of breast and ovary, and Hogdkin's lymphoma. We report a case of a 54-year-old male with acute-onset pancerebellar syndrome with underlying Hodgkin's lymphoma. A high index of suspicion of PCD resulted in arriving at an early diagnosis of underlying Hodgkin's disease. The patient was managed with six cycles of chemotherapy, which resulted in clinical stabilization and reversal of magnetic resonance imaging abnormalities. Antitumor therapy appears to have a significant impact on reversing PCD and hence early diagnosis and intervention for the primary remains the corner stone in stabilizing the neurological condition. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3424800/ /pubmed/22919195 http://dx.doi.org/10.4103/0972-2327.99720 Text en Copyright: © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Suri, Vinit
Khan, Nadeem I.
Jadhao, Nilesh
Gupta, Rohan
spellingShingle Suri, Vinit
Khan, Nadeem I.
Jadhao, Nilesh
Gupta, Rohan
Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma
author_facet Suri, Vinit
Khan, Nadeem I.
Jadhao, Nilesh
Gupta, Rohan
author_sort Suri, Vinit
title Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma
title_short Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma
title_full Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma
title_fullStr Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma
title_full_unstemmed Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma
title_sort paraneoplastic cerebellar degeneration in hodgkin's lymphoma
description Paraneoplastic cerebellar degeneration (PCD) is a rare disorder presenting typically with acute or subacute severe cerebellar ataxia. PCD is most commonly associated with small cell lung cancer followed by adenocarcinoma of breast and ovary, and Hogdkin's lymphoma. We report a case of a 54-year-old male with acute-onset pancerebellar syndrome with underlying Hodgkin's lymphoma. A high index of suspicion of PCD resulted in arriving at an early diagnosis of underlying Hodgkin's disease. The patient was managed with six cycles of chemotherapy, which resulted in clinical stabilization and reversal of magnetic resonance imaging abnormalities. Antitumor therapy appears to have a significant impact on reversing PCD and hence early diagnosis and intervention for the primary remains the corner stone in stabilizing the neurological condition.
publisher Medknow Publications & Media Pvt Ltd
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424800/
_version_ 1611551218127077376

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