Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms
The hypocretins/orexins are comprised of two neuroexcitatory peptides that are synthesized exclusively within a circumscribed region of the lateral hypothalamus. These peptides project widely throughout the brain and interact with a variety of regions involved in the regulation of arousal-related pr...
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| Format: | Online |
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Frontiers Media S.A.
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423791/ |
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pubmed-34237912012-08-29 Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms Calipari, Erin S. España, Rodrigo A. Neuroscience The hypocretins/orexins are comprised of two neuroexcitatory peptides that are synthesized exclusively within a circumscribed region of the lateral hypothalamus. These peptides project widely throughout the brain and interact with a variety of regions involved in the regulation of arousal-related processes including those associated with motivated behavior. The current review focuses on emerging evidence indicating that the hypocretins influence reward and reinforcement processing via actions on the mesolimbic dopamine system. We discuss contemporary perspectives of hypocretin regulation of mesolimbic dopamine signaling in both drug free and drug states, as well as hypocretin regulation of behavioral responses to drugs of abuse, particularly as it relates to cocaine. Frontiers Media S.A. 2012-08-21 /pmc/articles/PMC3423791/ /pubmed/22933994 http://dx.doi.org/10.3389/fnbeh.2012.00054 Text en Copyright © 2012 Calipari and España. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Calipari, Erin S. España, Rodrigo A. |
| spellingShingle |
Calipari, Erin S. España, Rodrigo A. Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms |
| author_facet |
Calipari, Erin S. España, Rodrigo A. |
| author_sort |
Calipari, Erin S. |
| title |
Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms |
| title_short |
Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms |
| title_full |
Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms |
| title_fullStr |
Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms |
| title_full_unstemmed |
Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms |
| title_sort |
hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms |
| description |
The hypocretins/orexins are comprised of two neuroexcitatory peptides that are synthesized exclusively within a circumscribed region of the lateral hypothalamus. These peptides project widely throughout the brain and interact with a variety of regions involved in the regulation of arousal-related processes including those associated with motivated behavior. The current review focuses on emerging evidence indicating that the hypocretins influence reward and reinforcement processing via actions on the mesolimbic dopamine system. We discuss contemporary perspectives of hypocretin regulation of mesolimbic dopamine signaling in both drug free and drug states, as well as hypocretin regulation of behavioral responses to drugs of abuse, particularly as it relates to cocaine. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423791/ |
| _version_ |
1611550911601049600 |