Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH protein (1 mg/kg) had no effect on spontaneou...

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Bibliographic Details
Main Authors: Carroll, Marilyn E., Zlebnik, Natalie E., Anker, Justin J., Kosten, Thomas R., Orson, Frank M., Shen, Xiaoyun, Kinsey, Berma, Parks, Robin J., Gao, Yang, Brimijoin, Stephen
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422258/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422258/

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