Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules
Bim is a proapoptotic BH3-only Bcl-2 family member. In response to death stimuli, Bim dissociates from the dynein light chain 1 (DYNLL1/LC8), where it is inactive, and can then initiate Bax/Bak-mediated mitochondria-dependent apoptosis. We found that Bim depletion increases autophagosome synthesis i...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419265/ |