A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier

Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We...

Full description

Bibliographic Details
Main Authors:	Bae, Joong Ho, Sohn, Joo Hyun, Lee, Hye Soon, Park, Hye Sun, Hyun, Yil Sik, Kim, Tae Yeob, Eun, Chang Soo, Jeon, Yong Cheol, Han, Dong Soo
Format:	Online
Language:	English
Published:	The Korean Association for the Study of the Liver 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415881/

id	pubmed-3415881
recordtype	oai_dc
spelling	pubmed-34158812012-08-14 A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier Bae, Joong Ho Sohn, Joo Hyun Lee, Hye Soon Park, Hye Sun Hyun, Yil Sik Kim, Tae Yeob Eun, Chang Soo Jeon, Yong Cheol Han, Dong Soo Case Report Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV. The Korean Association for the Study of the Liver 2012-06 2012-06-26 /pmc/articles/PMC3415881/ /pubmed/22893874 http://dx.doi.org/10.3350/cmh.2012.18.2.225 Text en Copyright © 2012 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bae, Joong Ho Sohn, Joo Hyun Lee, Hye Soon Park, Hye Sun Hyun, Yil Sik Kim, Tae Yeob Eun, Chang Soo Jeon, Yong Cheol Han, Dong Soo
spellingShingle	Bae, Joong Ho Sohn, Joo Hyun Lee, Hye Soon Park, Hye Sun Hyun, Yil Sik Kim, Tae Yeob Eun, Chang Soo Jeon, Yong Cheol Han, Dong Soo A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
author_facet	Bae, Joong Ho Sohn, Joo Hyun Lee, Hye Soon Park, Hye Sun Hyun, Yil Sik Kim, Tae Yeob Eun, Chang Soo Jeon, Yong Cheol Han, Dong Soo
author_sort	Bae, Joong Ho
title	A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_short	A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_full	A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_fullStr	A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_full_unstemmed	A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_sort	fatal case of hepatitis b virus (hbv) reactivation during long-term, very-low-dose steroid treatment in an inactive hbv carrier
description	Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV.
publisher	The Korean Association for the Study of the Liver
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415881/
_version_	1611548943806627840

A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier

Similar Items