Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression

Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression

We implemented least absolute shrinkage and selection operator (LASSO) regression to evaluate gene effects in genome-wide association studies (GWAS) of brain images, using an MRI-derived temporal lobe volume measure from 729 subjects scanned as part of the Alzheimer’s Disease Neuroimaging Initiative...

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Bibliographic Details
Main Authors: Kohannim, Omid, Hibar, Derrek P., Stein, Jason L., Jahanshad, Neda, Hua, Xue, Rajagopalan, Priya, Toga, Arthur W., Jack, Clifford R., Weiner, Michael W., de Zubicaray, Greig I., McMahon, Katie L., Hansell, Narelle K., Martin, Nicholas G., Wright, Margaret J., Thompson, Paul M.
Format: Online
Language:English
Published: Frontiers Research Foundation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412288/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412288/

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