Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring
Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m3 Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 1...
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Informa Healthcare
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411122/ |
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pubmed-34111222012-08-03 Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring Jackson, Petra Hougaard, Karin Sørig Boisen, Anne Mette Z. Jacobsen, Nicklas Raun Jensen, Keld Alstrup Møller, Peter Brunborg, Gunnar Gutzkow, Kristine Bjerve Andersen, Ole Loft, Steffen Vogel, Ulla Wallin, Håkan Origional Articles Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m3 Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 (μg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3-5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring. Informa Healthcare 2012-08 2012-06-08 /pmc/articles/PMC3411122/ /pubmed/21649560 http://dx.doi.org/10.3109/17435390.2011.587902 Text en © 2012 Informa UK Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Informa Healthcare journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jackson, Petra Hougaard, Karin Sørig Boisen, Anne Mette Z. Jacobsen, Nicklas Raun Jensen, Keld Alstrup Møller, Peter Brunborg, Gunnar Gutzkow, Kristine Bjerve Andersen, Ole Loft, Steffen Vogel, Ulla Wallin, Håkan |
| spellingShingle |
Jackson, Petra Hougaard, Karin Sørig Boisen, Anne Mette Z. Jacobsen, Nicklas Raun Jensen, Keld Alstrup Møller, Peter Brunborg, Gunnar Gutzkow, Kristine Bjerve Andersen, Ole Loft, Steffen Vogel, Ulla Wallin, Håkan Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring |
| author_facet |
Jackson, Petra Hougaard, Karin Sørig Boisen, Anne Mette Z. Jacobsen, Nicklas Raun Jensen, Keld Alstrup Møller, Peter Brunborg, Gunnar Gutzkow, Kristine Bjerve Andersen, Ole Loft, Steffen Vogel, Ulla Wallin, Håkan |
| author_sort |
Jackson, Petra |
| title |
Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring |
| title_short |
Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring |
| title_full |
Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring |
| title_fullStr |
Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring |
| title_full_unstemmed |
Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring |
| title_sort |
pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: effects on liver dna strand breaks in dams and offspring |
| description |
Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m3 Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 (μg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3-5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring. |
| publisher |
Informa Healthcare |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411122/ |
| _version_ |
1611547386257080320 |