“Mixed germ cell testicular tumor” in an adult female
The androgen insensitivity (testicular feminization) syndrome was described by Morris in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or scanty pubic or axillary hair. Gonads consist usually of seminiferous tubules without sperma...
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| Format: | Online |
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Medknow Publications & Media Pvt Ltd
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409924/ |
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pubmed-3409924 |
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pubmed-34099242012-08-06 “Mixed germ cell testicular tumor” in an adult female Shivakumarswamy, Udasimath Purushotham, R Naik, HK Kumar Nagesha, KR Case Report The androgen insensitivity (testicular feminization) syndrome was described by Morris in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or scanty pubic or axillary hair. Gonads consist usually of seminiferous tubules without spermatogenesis. These patients have a 5–10% risk of developing germ cell tumors, usually after the complete development of secondary female sexual characteristics. We hereby report a case considered as a female with married life of 15 years, who was operated for severe abdominal pain. Phenotype characters were that of female. Microscopic examination of the tumor from the abdomen revealed germinoma and yolk sac tumor with adjacent seminiferous tubules. Karyotyping showed 46XY. Final diagnosis of malignant mixed germ cell tumor in androgen insensitivity syndrome was made. Surveillance may be the most appropriate option when these conditions are initially diagnosed in adulthood to prevent development of germ cell tumors. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3409924/ /pubmed/22870019 http://dx.doi.org/10.4103/0974-1208.97810 Text en Copyright: © Journal of Human Reproductive Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Shivakumarswamy, Udasimath Purushotham, R Naik, HK Kumar Nagesha, KR |
| spellingShingle |
Shivakumarswamy, Udasimath Purushotham, R Naik, HK Kumar Nagesha, KR “Mixed germ cell testicular tumor” in an adult female |
| author_facet |
Shivakumarswamy, Udasimath Purushotham, R Naik, HK Kumar Nagesha, KR |
| author_sort |
Shivakumarswamy, Udasimath |
| title |
“Mixed germ cell testicular tumor” in an adult female |
| title_short |
“Mixed germ cell testicular tumor” in an adult female |
| title_full |
“Mixed germ cell testicular tumor” in an adult female |
| title_fullStr |
“Mixed germ cell testicular tumor” in an adult female |
| title_full_unstemmed |
“Mixed germ cell testicular tumor” in an adult female |
| title_sort |
“mixed germ cell testicular tumor” in an adult female |
| description |
The androgen insensitivity (testicular feminization) syndrome was described by Morris in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or scanty pubic or axillary hair. Gonads consist usually of seminiferous tubules without spermatogenesis. These patients have a 5–10% risk of developing germ cell tumors, usually after the complete development of secondary female sexual characteristics. We hereby report a case considered as a female with married life of 15 years, who was operated for severe abdominal pain. Phenotype characters were that of female. Microscopic examination of the tumor from the abdomen revealed germinoma and yolk sac tumor with adjacent seminiferous tubules. Karyotyping showed 46XY. Final diagnosis of malignant mixed germ cell tumor in androgen insensitivity syndrome was made. Surveillance may be the most appropriate option when these conditions are initially diagnosed in adulthood to prevent development of germ cell tumors. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409924/ |
| _version_ |
1611546984011792384 |