Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo
The P140K point mutant of MGMT allows robust hematopoietic stem cell (HSC) enrichment in vivo. Thus, dual-gene vectors that couple MGMT and therapeutic gene expression have allowed enrichment of gene-corrected HSCs in animal models. However, expression levels from dual-gene vectors are often reduced...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
International Scholarly Research Network
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408655/ |