Cyclic AMP regulates formation of mammary epithelial acini in vitro

Cyclic AMP–dependent protein kinase A (PKA) is required for MCF10A mammary epithelial acinus formation in vitro. PKA plays a dual role by facilitating polarization of cells attached to the extracellular matrix and apoptosis of detached cells.

Bibliographic Details
Main Authors: Nedvetsky, Pavel I., Kwon, Sang-Ho, Debnath, Jayanta, Mostov, Keith E.
Format: Online
Language:English
Published: The American Society for Cell Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408423/