In vivo models of primary brain tumors: pitfalls and perspectives

Animal modeling for primary brain tumors has undergone constant development over the last 60 years, and significant improvements have been made recently with the establishment of highly invasive glioblastoma models. In this review we discuss the advantages and pitfalls of model development, focusing...

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Main Authors:	Huszthy, Peter C., Daphu, Inderjit, Niclou, Simone P., Stieber, Daniel, Nigro, Janice M., Sakariassen, Per Ø., Miletic, Hrvoje, Thorsen, Frits, Bjerkvig, Rolf
Format:	Online
Language:	English
Published:	Oxford University Press 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408261/

id	pubmed-3408261
recordtype	oai_dc
spelling	pubmed-34082612012-07-30 In vivo models of primary brain tumors: pitfalls and perspectives Huszthy, Peter C. Daphu, Inderjit Niclou, Simone P. Stieber, Daniel Nigro, Janice M. Sakariassen, Per Ø. Miletic, Hrvoje Thorsen, Frits Bjerkvig, Rolf Reviews Animal modeling for primary brain tumors has undergone constant development over the last 60 years, and significant improvements have been made recently with the establishment of highly invasive glioblastoma models. In this review we discuss the advantages and pitfalls of model development, focusing on chemically induced models, various xenogeneic grafts of human cell lines, including stem cell–like cell lines and biopsy spheroids. We then discuss the development of numerous genetically engineered models available to study mechanisms of tumor initiation and progression. At present it is clear that none of the current animal models fully reflects human gliomas. Yet, the various model systems have provided important insight into specific mechanisms of tumor development. In particular, it is anticipated that a combined comprehensive knowledge of the various models currently available will provide important new knowledge on target identification and the validation and development of new therapeutic strategies. Oxford University Press 2012-08 2012-06-07 /pmc/articles/PMC3408261/ /pubmed/22679124 http://dx.doi.org/10.1093/neuonc/nos135 Text en © The Author 2012. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. http://creativecommons.org/licenses/by-nc/2.5/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Huszthy, Peter C. Daphu, Inderjit Niclou, Simone P. Stieber, Daniel Nigro, Janice M. Sakariassen, Per Ø. Miletic, Hrvoje Thorsen, Frits Bjerkvig, Rolf
spellingShingle	Huszthy, Peter C. Daphu, Inderjit Niclou, Simone P. Stieber, Daniel Nigro, Janice M. Sakariassen, Per Ø. Miletic, Hrvoje Thorsen, Frits Bjerkvig, Rolf In vivo models of primary brain tumors: pitfalls and perspectives
author_facet	Huszthy, Peter C. Daphu, Inderjit Niclou, Simone P. Stieber, Daniel Nigro, Janice M. Sakariassen, Per Ø. Miletic, Hrvoje Thorsen, Frits Bjerkvig, Rolf
author_sort	Huszthy, Peter C.
title	In vivo models of primary brain tumors: pitfalls and perspectives
title_short	In vivo models of primary brain tumors: pitfalls and perspectives
title_full	In vivo models of primary brain tumors: pitfalls and perspectives
title_fullStr	In vivo models of primary brain tumors: pitfalls and perspectives
title_full_unstemmed	In vivo models of primary brain tumors: pitfalls and perspectives
title_sort	in vivo models of primary brain tumors: pitfalls and perspectives
description	Animal modeling for primary brain tumors has undergone constant development over the last 60 years, and significant improvements have been made recently with the establishment of highly invasive glioblastoma models. In this review we discuss the advantages and pitfalls of model development, focusing on chemically induced models, various xenogeneic grafts of human cell lines, including stem cell–like cell lines and biopsy spheroids. We then discuss the development of numerous genetically engineered models available to study mechanisms of tumor initiation and progression. At present it is clear that none of the current animal models fully reflects human gliomas. Yet, the various model systems have provided important insight into specific mechanisms of tumor development. In particular, it is anticipated that a combined comprehensive knowledge of the various models currently available will provide important new knowledge on target identification and the validation and development of new therapeutic strategies.
publisher	Oxford University Press
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408261/
_version_	1611546443419484160

In vivo models of primary brain tumors: pitfalls and perspectives

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