Structural Basis of Evasion of Cellular Adaptive Immunity by HIV-1 Nef
The HIV-1 protein Nef inhibits antigen presentation by class I MHC (MHC-I). Here the mechanism of this activity is revealed by the crystal structure of a protein complex consisting of Nef, the MHC-I cytoplasmic domain (MHC-I CD), and the μ1 subunit of the clathrin adaptor protein complex 1. A ternar...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407041/ |