Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To addres...

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Bibliographic Details
Main Authors: Neu, Ursula, Hengel, Holger, Blaum, Bärbel S., Schowalter, Rachel M., Macejak, Dennis, Gilbert, Michel, Wakarchuk, Warren W., Imamura, Akihiro, Ando, Hiromune, Kiso, Makoto, Arnberg, Niklas, Garcea, Robert L., Peters, Thomas, Buck, Christopher B., Stehle, Thilo
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406085/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406085/

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