Inhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits

Inhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits

► Small hairpin RNA specific for SR-BI nucleotides 214-232 reduces SR-BI expression in vitro. ► SiRNA treatment reduces liver expression of SR-BI in New Zealand White rabbits. ► Liver specific inhibition of SR-BI leads to a 50% reduction of atherosclerosis in cholesterol fed rabbits. ► The role of S...

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Main Authors: Demetz, Egon, Tancevski, Ivan, Duwensee, Kristina, Stanzl, Ursula, Huber, Eva, Heim, Christiane, Handle, Florian, Theurl, Markus, Schroll, Andrea, Tailleux, Anne, Dietrich, Hermann, Patsch, Josef R., Eller, Philipp, Ritsch, Andreas
Format: Online
Language:English
Published: Elsevier 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405511/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405511/

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