Non-invasive prenatal diagnosis using cell-free fetal nucleic acids in maternal plasma: Progress overview beyond predictive and personalized diagnosis

The discovery of circulating cell-free fetal DNA (cffDNA) in maternal plasma allowed for the development of alternative methodologies that may facilitate safe non-invasive prenatal diagnosis (NIPD). The low concentration of cffDNA in maternal plasma, however, and the coexistence of maternal DNA limi...

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Bibliographic Details
Main Authors: Tounta, Georgia, Kolialexi, Aggeliki, Papantoniou, Nikolas, Tsangaris, George Th., Kanavakis, Emmanuel, Mavrou, Ariadni
Format: Online
Language:English
Published: Springer Netherlands 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405386/