Antitumoral Efficacy of the Protease Inhibitor Gabexate Mesilate in Colon Cancer Cells Harbouring KRAS, BRAF and PIK3CA Mutations

Antitumoral Efficacy of the Protease Inhibitor Gabexate Mesilate in Colon Cancer Cells Harbouring KRAS, BRAF and PIK3CA Mutations

The employment of anti-epidermal growth factor receptor (EGFR) antibodies represents a backbone of the therapeutic options for the treatment of metastatic colorectal cancer (mCRC). However, this therapy is poorly effective or ineffective in unselected patients. Mutations in KRAS, BRAF and PIK3CA gen...

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Bibliographic Details
Main Authors: Brandi, Giovanni, Tavolari, Simona, De Rosa, Francesco, Di Girolamo, Stefania, Agostini, Valentina, Barbera, Maria Aurelia, Frega, Giorgio, Biasco, Guido
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404056/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404056/

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