The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity

The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns and immune-compromised adults. The pore-forming toxin (PFT) β hemolysin/cytolysin (βh/c) is a major virulence factor for GBS, which is generally attributed to its cytolytic functions. Here we show βh/c...

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Bibliographic Details
Main Authors: Bebien, Magali, Hensler, Mary E., Davanture, Suzel, Hsu, Li-Chung, Karin, Michael, Park, Jin Mo, Alexopoulou, Lena, Liu, George Y., Nizet, Victor, Lawrence, Toby
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400567/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400567/

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