Genesis of tramsmissible protein states via deformed templating
Prion replication occurs via a template-assisted mechanism, which postulates that the folding pattern of a newly recruited polypeptide chain accurately reproduces that of a template. The concept of prion-like template-assisted propagation of an abnormal protein conformation has been expanded to amyl...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Landes Bioscience
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399541/ |