Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus
The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantat...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399403/ |
| id |
pubmed-3399403 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-33994032012-07-24 Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus Wang, Dandan Akiyama, Kentaro Zhang, Huayong Yamaza, Takayoshi Li, Xia Feng, Xuebing Wang, Hong Hua, Bingzhu Liu, Bujun Xu, Huji Chen, Wanjun Shi, Songtao Sun, Lingyun Clinical Study The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation. Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT. Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events. SLE disease activity index (SLEDAI) and serologic features were evaluated. Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup. This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients. Hindawi Publishing Corporation 2012 2012-07-09 /pmc/articles/PMC3399403/ /pubmed/22829849 http://dx.doi.org/10.1155/2012/273291 Text en Copyright © 2012 Dandan Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Wang, Dandan Akiyama, Kentaro Zhang, Huayong Yamaza, Takayoshi Li, Xia Feng, Xuebing Wang, Hong Hua, Bingzhu Liu, Bujun Xu, Huji Chen, Wanjun Shi, Songtao Sun, Lingyun |
| spellingShingle |
Wang, Dandan Akiyama, Kentaro Zhang, Huayong Yamaza, Takayoshi Li, Xia Feng, Xuebing Wang, Hong Hua, Bingzhu Liu, Bujun Xu, Huji Chen, Wanjun Shi, Songtao Sun, Lingyun Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| author_facet |
Wang, Dandan Akiyama, Kentaro Zhang, Huayong Yamaza, Takayoshi Li, Xia Feng, Xuebing Wang, Hong Hua, Bingzhu Liu, Bujun Xu, Huji Chen, Wanjun Shi, Songtao Sun, Lingyun |
| author_sort |
Wang, Dandan |
| title |
Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_short |
Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_full |
Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_fullStr |
Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_full_unstemmed |
Double Allogenic Mesenchymal Stem Cells Transplantations Could Not
Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus |
| title_sort |
double allogenic mesenchymal stem cells transplantations could not
enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus |
| description |
The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation. Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT. Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events. SLE disease activity index (SLEDAI) and serologic features were evaluated. Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup. This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399403/ |
| _version_ |
1611543799270473728 |