Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals
Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found...
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| Format: | Online |
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MDPI
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397454/ |
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pubmed-3397454 |
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pubmed-33974542012-07-20 Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals Suarez-Jimenez, Guadalupe-Miroslava Burgos-Hernandez, Armando Ezquerra-Brauer, Josafat-Marina Review Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabolites from sponges, ascidians, tunicates, and mollusks. The structural characteristics of these peptides include various unusual amino acid residues which may be responsible for their bioactivity. Moreover, protein hydrolysates formed by the enzymatic digestion of aquatic and marine by-products are an important source of bioactive peptides. Purified peptides from these sources have been shown to have antioxidant activity and cytotoxic effect on several human cancer cell lines such as HeLa, AGS, and DLD-1. These characteristics imply that the use of peptides from marine sources has potential for the prevention and treatment of cancer, and that they might also be useful as molecular models in anticancer drug research. This review focuses on the latest studies and critical research in this field, and evidences the immense potential of marine animals as bioactive peptide sources. MDPI 2012-04-26 /pmc/articles/PMC3397454/ /pubmed/22822350 http://dx.doi.org/10.3390/md10050963 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Suarez-Jimenez, Guadalupe-Miroslava Burgos-Hernandez, Armando Ezquerra-Brauer, Josafat-Marina |
| spellingShingle |
Suarez-Jimenez, Guadalupe-Miroslava Burgos-Hernandez, Armando Ezquerra-Brauer, Josafat-Marina Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals |
| author_facet |
Suarez-Jimenez, Guadalupe-Miroslava Burgos-Hernandez, Armando Ezquerra-Brauer, Josafat-Marina |
| author_sort |
Suarez-Jimenez, Guadalupe-Miroslava |
| title |
Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals |
| title_short |
Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals |
| title_full |
Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals |
| title_fullStr |
Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals |
| title_full_unstemmed |
Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals |
| title_sort |
bioactive peptides and depsipeptides with anticancer potential: sources from marine animals |
| description |
Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabolites from sponges, ascidians, tunicates, and mollusks. The structural characteristics of these peptides include various unusual amino acid residues which may be responsible for their bioactivity. Moreover, protein hydrolysates formed by the enzymatic digestion of aquatic and marine by-products are an important source of bioactive peptides. Purified peptides from these sources have been shown to have antioxidant activity and cytotoxic effect on several human cancer cell lines such as HeLa, AGS, and DLD-1. These characteristics imply that the use of peptides from marine sources has potential for the prevention and treatment of cancer, and that they might also be useful as molecular models in anticancer drug research. This review focuses on the latest studies and critical research in this field, and evidences the immense potential of marine animals as bioactive peptide sources. |
| publisher |
MDPI |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397454/ |
| _version_ |
1611543227467300864 |