Blood-brain barrier and retroviral infections

Homeostasis in the central nervous system (CNS) is maintained by active interfaces between the bloodstream and the brain parenchyma. The blood-brain barrier (BBB) constitutes a selective filter for exchange of water, solutes, nutrients, and controls toxic compounds or pathogens entry. Some parasites...

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Main Authors:	Miller, Florence, Afonso, Philippe V., Gessain, Antoine, Ceccaldi, Pierre-Emmanuel
Format:	Online
Language:	English
Published:	Landes Bioscience 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396701/

id	pubmed-3396701
recordtype	oai_dc
spelling	pubmed-33967012012-07-16 Blood-brain barrier and retroviral infections Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel Review Homeostasis in the central nervous system (CNS) is maintained by active interfaces between the bloodstream and the brain parenchyma. The blood-brain barrier (BBB) constitutes a selective filter for exchange of water, solutes, nutrients, and controls toxic compounds or pathogens entry. Some parasites, bacteria, and viruses have however developed various CNS invasion strategies, and can bypass the brain barriers. Concerning viruses, these strategies include transport along neural pathways, transcytosis, infection of the brain endothelial cells, breaching of the BBB, and passage of infected-leukocytes. Moreover, neurotropic viruses can alter BBB functions, thus compromising CNS homeostasis. Retroviruses have been associated to human neurological diseases: HIV (human immunodeficiency virus 1) can induce HIV-associated dementia, and HTLV-1 (human T lymphotropic virus 1) is the etiological factor of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). The present review focuses on how the different retroviruses interact with this structure, bypass it and alter its functions. Landes Bioscience 2012-03-01 /pmc/articles/PMC3396701/ /pubmed/22460635 http://dx.doi.org/10.4161/viru.19697 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel
spellingShingle	Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel Blood-brain barrier and retroviral infections
author_facet	Miller, Florence Afonso, Philippe V. Gessain, Antoine Ceccaldi, Pierre-Emmanuel
author_sort	Miller, Florence
title	Blood-brain barrier and retroviral infections
title_short	Blood-brain barrier and retroviral infections
title_full	Blood-brain barrier and retroviral infections
title_fullStr	Blood-brain barrier and retroviral infections
title_full_unstemmed	Blood-brain barrier and retroviral infections
title_sort	blood-brain barrier and retroviral infections
description	Homeostasis in the central nervous system (CNS) is maintained by active interfaces between the bloodstream and the brain parenchyma. The blood-brain barrier (BBB) constitutes a selective filter for exchange of water, solutes, nutrients, and controls toxic compounds or pathogens entry. Some parasites, bacteria, and viruses have however developed various CNS invasion strategies, and can bypass the brain barriers. Concerning viruses, these strategies include transport along neural pathways, transcytosis, infection of the brain endothelial cells, breaching of the BBB, and passage of infected-leukocytes. Moreover, neurotropic viruses can alter BBB functions, thus compromising CNS homeostasis. Retroviruses have been associated to human neurological diseases: HIV (human immunodeficiency virus 1) can induce HIV-associated dementia, and HTLV-1 (human T lymphotropic virus 1) is the etiological factor of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). The present review focuses on how the different retroviruses interact with this structure, bypass it and alter its functions.
publisher	Landes Bioscience
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396701/
_version_	1611543110666420224

Blood-brain barrier and retroviral infections

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