Sustained Exendin-4 Secretion through Gene Therapy Targeting Salivary Glands in Two Different Rodent Models of Obesity/Type 2 Diabetes

Sustained Exendin-4 Secretion through Gene Therapy Targeting Salivary Glands in Two Different Rodent Models of Obesity/Type 2 Diabetes

Exendin-4 (Ex-4) is a Glucagon-like peptide 1 (GLP-1) receptor agonist approved for the treatment of Type 2 Diabetes (T2DM), which requires daily subcutaneous administration. In T2DM patients, GLP-1 administration is reported to reduce glycaemia and HbA1c in association with a modest, but significan...

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Bibliographic Details
Main Authors: Di Pasquale, Giovanni, Dicembrini, Ilaria, Raimondi, Laura, Pagano, Claudio, Egan, Josephine M., Cozzi, Andrea, Cinci, Lorenzo, Loreto, Andrea, Manni, Maria E., Berretti, Silvia, Morelli, Annamaria, Zheng, Changyu, Michael, Drew G., Maggi, Mario, Vettor, Roberto, Chiorini, John A., Mannucci, Edoardo, Rotella, Carlo M.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396615/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396615/

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