In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy

In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy

Optical spectroscopy has proven to be a powerful technique for studying neoplastic transformation in epithelial tissue. Since specific intra-layer precancerous changes originate in the stratified layers of the oral mucosa, layer-resolved analysis will likely improve both our understanding of the mec...

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Main Authors: Edward, Kert, Qiu, Suimin, Resto, Vicente, McCammon, Susan, Vargas, Gracie
Format: Online
Language:English
Published: Optical Society of America 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395483/
id pubmed-3395483
recordtype oai_dc
spelling pubmed-33954832012-07-17 In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy Edward, Kert Qiu, Suimin Resto, Vicente McCammon, Susan Vargas, Gracie Optics in Cancer Research Optical spectroscopy has proven to be a powerful technique for studying neoplastic transformation in epithelial tissue. Since specific intra-layer precancerous changes originate in the stratified layers of the oral mucosa, layer-resolved analysis will likely improve both our understanding of the mechanism of premalignant transformation, and clinical diagnostic outcomes. However, the native fluorescence signal in linear spectroscopy typically originates from a multi-layered focal volume. In this study, nonlinear spectroscopy was exploited for in vivo layer-resolved discrimination between normal and dysplastic tissue for the first time. Our results revealed numerous intra-layer specific differences. Optical Society of America 2012-06-12 /pmc/articles/PMC3395483/ /pubmed/22808430 http://dx.doi.org/10.1364/BOE.3.001579 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Edward, Kert
Qiu, Suimin
Resto, Vicente
McCammon, Susan
Vargas, Gracie
spellingShingle Edward, Kert
Qiu, Suimin
Resto, Vicente
McCammon, Susan
Vargas, Gracie
In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy
author_facet Edward, Kert
Qiu, Suimin
Resto, Vicente
McCammon, Susan
Vargas, Gracie
author_sort Edward, Kert
title In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy
title_short In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy
title_full In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy
title_fullStr In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy
title_full_unstemmed In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy
title_sort in vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy
description Optical spectroscopy has proven to be a powerful technique for studying neoplastic transformation in epithelial tissue. Since specific intra-layer precancerous changes originate in the stratified layers of the oral mucosa, layer-resolved analysis will likely improve both our understanding of the mechanism of premalignant transformation, and clinical diagnostic outcomes. However, the native fluorescence signal in linear spectroscopy typically originates from a multi-layered focal volume. In this study, nonlinear spectroscopy was exploited for in vivo layer-resolved discrimination between normal and dysplastic tissue for the first time. Our results revealed numerous intra-layer specific differences.
publisher Optical Society of America
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395483/
_version_ 1611542727526187008

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