Control and Augmentation of Long-Term Plasmid Transgene Expression In Vivo in Murine Muscle Tissue and Ex Vivo in Patient Mesenchymal Tissue

Control and Augmentation of Long-Term Plasmid Transgene Expression In Vivo in Murine Muscle Tissue and Ex Vivo in Patient Mesenchymal Tissue

Purpose. In vivo gene therapy directed at tissues of mesenchymal origin could potentially augment healing. We aimed to assess the duration and magnitude of transene expression in vivo in mice and ex vivo in human tissues. Methods. Using bioluminescence imaging, plasmid and adenoviral vector-based t...

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Bibliographic Details
Main Authors: Morrissey, David, van Pijkeren, Jan P., Rajendran, Simon, Collins, Sara A., Casey, Garrett, O'Sullivan, Gerald C., Tangney, Mark
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395381/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395381/

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