Ubiquitylation of Terminal Deoxynucleotidyltransferase Inhibits Its Activity

Ubiquitylation of Terminal Deoxynucleotidyltransferase Inhibits Its Activity

Terminal deoxynucleotidyltransferase (TdT), which template-independently synthesizes DNA during V(D)J recombination in lymphoid cells, is ubiquitylated by a BPOZ-2/Cul3 complex, as the ubiquitin ligase, and then degraded by the 26 S proteasome. We show here that TdT is ubiquitylated by the Cul3-base...

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Bibliographic Details
Main Authors: Maezawa, So, Fukushima, Rie, Matsushita, Toyofumi, Kato, Tomoyoshi, Takagaki, Yoshiki, Nishiyama, Yoshihiro, Ando, Sachiko, Matsumoto, Takuro, Kouda, Kousuke, Hayano, Takahide, Suzuki, Masahiro, Koiwai, Kotaro, Koiwai, Osamu
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394778/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394778/

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