Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice

The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological safety is the most important factor when considering the clinical application of CNTs as biomaterials, and various toxici...

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Main Authors:	Takanashi, Seiji, Hara, Kazuo, Aoki, Kaoru, Usui, Yuki, Shimizu, Masayuki, Haniu, Hisao, Ogihara, Nobuhide, Ishigaki, Norio, Nakamura, Koichi, Okamoto, Masanori, Kobayashi, Shinsuke, Kato, Hiroyuki, Sano, Kenji, Nishimura, Naoyuki, Tsutsumi, Hideki, Machida, Kazuhiko, Saito, Naoto
Format:	Online
Language:	English
Published:	Nature Publishing Group 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391660/

id	pubmed-3391660
recordtype	oai_dc
spelling	pubmed-33916602012-07-11 Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice Takanashi, Seiji Hara, Kazuo Aoki, Kaoru Usui, Yuki Shimizu, Masayuki Haniu, Hisao Ogihara, Nobuhide Ishigaki, Norio Nakamura, Koichi Okamoto, Masanori Kobayashi, Shinsuke Kato, Hiroyuki Sano, Kenji Nishimura, Naoyuki Tsutsumi, Hideki Machida, Kazuhiko Saito, Naoto Article The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological safety is the most important factor when considering the clinical application of CNTs as biomaterials, and various toxicity evaluations are required. Among these evaluations, carcinogenicity should be examined with the highest priority; however, no report using transgenic mice to evaluate the carcinogenicity of CNTs has been published to date. Here, we performed a carcinogenicity test by implanting multi-walled CNTs (MWCNTs) into the subcutaneous tissue of rasH2 mice, using the carbon black present in black tattoo ink as a reference material for safety. The rasH2 mice did not develop neoplasms after being injected with MWCNTs; instead, MWCNTs showed lower carcinogenicity than carbon black. Such evaluations should facilitate the clinical application and development of CNTs for use in important medical fields. Nature Publishing Group 2012-07-09 /pmc/articles/PMC3391660/ /pubmed/22787556 http://dx.doi.org/10.1038/srep00498 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Takanashi, Seiji Hara, Kazuo Aoki, Kaoru Usui, Yuki Shimizu, Masayuki Haniu, Hisao Ogihara, Nobuhide Ishigaki, Norio Nakamura, Koichi Okamoto, Masanori Kobayashi, Shinsuke Kato, Hiroyuki Sano, Kenji Nishimura, Naoyuki Tsutsumi, Hideki Machida, Kazuhiko Saito, Naoto
spellingShingle	Takanashi, Seiji Hara, Kazuo Aoki, Kaoru Usui, Yuki Shimizu, Masayuki Haniu, Hisao Ogihara, Nobuhide Ishigaki, Norio Nakamura, Koichi Okamoto, Masanori Kobayashi, Shinsuke Kato, Hiroyuki Sano, Kenji Nishimura, Naoyuki Tsutsumi, Hideki Machida, Kazuhiko Saito, Naoto Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
author_facet	Takanashi, Seiji Hara, Kazuo Aoki, Kaoru Usui, Yuki Shimizu, Masayuki Haniu, Hisao Ogihara, Nobuhide Ishigaki, Norio Nakamura, Koichi Okamoto, Masanori Kobayashi, Shinsuke Kato, Hiroyuki Sano, Kenji Nishimura, Naoyuki Tsutsumi, Hideki Machida, Kazuhiko Saito, Naoto
author_sort	Takanashi, Seiji
title	Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
title_short	Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
title_full	Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
title_fullStr	Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
title_full_unstemmed	Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
title_sort	carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rash2 mice
description	The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological safety is the most important factor when considering the clinical application of CNTs as biomaterials, and various toxicity evaluations are required. Among these evaluations, carcinogenicity should be examined with the highest priority; however, no report using transgenic mice to evaluate the carcinogenicity of CNTs has been published to date. Here, we performed a carcinogenicity test by implanting multi-walled CNTs (MWCNTs) into the subcutaneous tissue of rasH2 mice, using the carbon black present in black tattoo ink as a reference material for safety. The rasH2 mice did not develop neoplasms after being injected with MWCNTs; instead, MWCNTs showed lower carcinogenicity than carbon black. Such evaluations should facilitate the clinical application and development of CNTs for use in important medical fields.
publisher	Nature Publishing Group
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391660/
_version_	1611541546860019712

Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice

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