Autocrine Role of Angiopoietins during Megakaryocytic Differentiation

The tyrosine kinase Tie-2 and its ligands Angiopoietins (Angs) transduce critical signals for angiogenesis in endothelial cells. This receptor and Ang-1 are coexpressed in hematopoietic stem cells and in a subset of megakaryocytes, though a possible role of angiopoietins in megakaryocytic differenti...

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Bibliographic Details
Main Authors: Saulle, Ernestina, Guerriero, Raffaella, Petronelli, Alessia, Coppotelli, Elena, Gabbianelli, Marco, Morsilli, Ornella, Spinello, Isabella, Pelosi, Elvira, Castelli, Germana, Testa, Ugo, Coppola, Simona
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391299/