Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models

Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models

Genetically modified mice provide a number of models for studying cardiac channelopathies related to cardiac Na+ channel (SCN5A) abnormalities. We review key pathophysiological features in these murine models that may underlie clinical features observed in sinus node dysfunction and progressive card...

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Bibliographic Details
Main Authors: Huang, Christopher L.-H., Lei, Lily, Matthews, Gareth D. K., Zhang, Yanmin, Lei, Ming
Format: Online
Language:English
Published: Frontiers Research Foundation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390692/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390692/

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