Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner

Transcription factor FoxO1 promotes hepatic glucose production. Genetic inhibition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identify pharmacological approaches to modulate its function. Altered Notch signaling is seen in tumorigenesis, and Notch antagon...

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Bibliographic Details
Main Authors: Pajvani, Utpal B., Shawber, Carrie J., Samuel, Varman T., Birkenfeld, Andreas L., Shulman, Gerald I., Kitajewski, Jan, Accili, Domenico
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387563/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387563/

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