Characterization of Coding Synonymous and Non-Synonymous Variants in ADAMTS13 Using Ex Vivo and In Silico Approaches

Characterization of Coding Synonymous and Non-Synonymous Variants in ADAMTS13 Using Ex Vivo and In Silico Approaches

Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s). However, mounting evidence shows that these “silent” variations can have a significant impact on prote...

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Bibliographic Details
Main Authors: Edwards, Nathan C., Hing, Zachary A., Perry, Avital, Blaisdell, Adam, Kopelman, David B., Fathke, Robert, Plum, William, Newell, Jordan, Allen, Courtni E., S., Geetha, Shapiro, Aaron, Okunji, Chinyere, Kosti, Idit, Shomron, Noam, Grigoryan, Vahan, Przytycka, Teresa M., Sauna, Zuben E., Salari, Raheleh, Mandel-Gutfreund, Yael, Komar, Anton A., Kimchi-Sarfaty, Chava
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387200/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387200/

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