Microtubules regulate GEF-H1 in response to extracellular matrix stiffness
Rho GTPase plays a role in mechanosensing, and breast epithelial cells sense the stiffness of the extracellular matrix through Rho-mediated contractility. Microtubule stability is reduced by a stiff matrix, which leads to the activation of the Rho exchange factor GEF-H1.
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386221/ |