Extensive Evolutionary Changes in Regulatory Element Activity during Human Origins Are Associated with Altered Gene Expression and Positive Selection

Extensive Evolutionary Changes in Regulatory Element Activity during Human Origins Are Associated with Altered Gene Expression and Positive Selection

Understanding the molecular basis for phenotypic differences between humans and other primates remains an outstanding challenge. Mutations in non-coding regulatory DNA that alter gene expression have been hypothesized as a key driver of these phenotypic differences. This has been supported by differ...

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Bibliographic Details
Main Authors: Shibata, Yoichiro, Sheffield, Nathan C., Fedrigo, Olivier, Babbitt, Courtney C., Wortham, Matthew, Tewari, Alok K., London, Darin, Song, Lingyun, Lee, Bum-Kyu, Iyer, Vishwanath R., Parker, Stephen C. J., Margulies, Elliott H., Wray, Gregory A., Furey, Terrence S., Crawford, Gregory E.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386175/

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