Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

Electroporation (EP) of mammalian tissue is a technique that has been used successfully in the clinic for the delivery of genetic-based vaccines in the form of DNA plasmids. There is great interest in platforms which efficiently deliver RNA molecules such as messenger RNA and small interfering RNA (...

Full description

Bibliographic Details
Main Authors: Broderick, Kate E, Chan, Amy, Lin, Feng, Shen, Xuefei, Kichaev, Gleb, Khan, Amir S, Aubin, Justin, Zimmermann, Tracy S, Sardesai, Niranjan Y.
Format: Online
Language:English
Published: Nature Publishing Group 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381603/