Task-Dependent Modulation of Effective Connectivity within the Default Mode Network

The default mode network (DMN) has recently attracted widespread interest. Previous studies have found that task-related processing can induce deactivation and changes in the functional connectivity of this network. However, it remains unclear how tasks modulate the underlying effective connectivity...

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Main Authors:	Li, Baojuan, Wang, Xiang, Yao, Shuqiao, Hu, Dewen, Friston, Karl
Format:	Online
Language:	English
Published:	Frontiers Research Foundation 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381220/

id	pubmed-3381220
recordtype	oai_dc
spelling	pubmed-33812202012-06-26 Task-Dependent Modulation of Effective Connectivity within the Default Mode Network Li, Baojuan Wang, Xiang Yao, Shuqiao Hu, Dewen Friston, Karl Psychology The default mode network (DMN) has recently attracted widespread interest. Previous studies have found that task-related processing can induce deactivation and changes in the functional connectivity of this network. However, it remains unclear how tasks modulate the underlying effective connectivity within the DMN. Using recent advances in dynamic causal modeling (DCM), we investigated the modulatory effect of (gender judgment) task performance on directed connectivity within the DMN. Sixteen healthy subjects were scanned twice: at rest and while performing a gender judgment task. Group independent component analysis was used to identify independent spatial components. Four subject-specific regions of interest (ROIs) were defined according to the ensuing default mode component: the posterior cingulate cortex, the left lateral parietal cortex, the right lateral parietal cortex, and the medial prefrontal cortex. Effective connectivity among these regions was then characterized with stochastic DCM, revealing enhanced (extrinsic) between region connectivity within the DMN during task sessions – and a universal decrease in (intrinsic) self-inhibition – relative to resting sessions. These results suggest a distributed but systematic modulatory effect of cognitive and attentional set on the effective connectivity subtending the DMN: an effect that increases its sensitivity to inputs and may optimize distributed processing during task performance. Frontiers Research Foundation 2012-06-22 /pmc/articles/PMC3381220/ /pubmed/22737141 http://dx.doi.org/10.3389/fpsyg.2012.00206 Text en Copyright © 2012 Li, Wang, Yao, Hu and Friston. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Li, Baojuan Wang, Xiang Yao, Shuqiao Hu, Dewen Friston, Karl
spellingShingle	Li, Baojuan Wang, Xiang Yao, Shuqiao Hu, Dewen Friston, Karl Task-Dependent Modulation of Effective Connectivity within the Default Mode Network
author_facet	Li, Baojuan Wang, Xiang Yao, Shuqiao Hu, Dewen Friston, Karl
author_sort	Li, Baojuan
title	Task-Dependent Modulation of Effective Connectivity within the Default Mode Network
title_short	Task-Dependent Modulation of Effective Connectivity within the Default Mode Network
title_full	Task-Dependent Modulation of Effective Connectivity within the Default Mode Network
title_fullStr	Task-Dependent Modulation of Effective Connectivity within the Default Mode Network
title_full_unstemmed	Task-Dependent Modulation of Effective Connectivity within the Default Mode Network
title_sort	task-dependent modulation of effective connectivity within the default mode network
description	The default mode network (DMN) has recently attracted widespread interest. Previous studies have found that task-related processing can induce deactivation and changes in the functional connectivity of this network. However, it remains unclear how tasks modulate the underlying effective connectivity within the DMN. Using recent advances in dynamic causal modeling (DCM), we investigated the modulatory effect of (gender judgment) task performance on directed connectivity within the DMN. Sixteen healthy subjects were scanned twice: at rest and while performing a gender judgment task. Group independent component analysis was used to identify independent spatial components. Four subject-specific regions of interest (ROIs) were defined according to the ensuing default mode component: the posterior cingulate cortex, the left lateral parietal cortex, the right lateral parietal cortex, and the medial prefrontal cortex. Effective connectivity among these regions was then characterized with stochastic DCM, revealing enhanced (extrinsic) between region connectivity within the DMN during task sessions – and a universal decrease in (intrinsic) self-inhibition – relative to resting sessions. These results suggest a distributed but systematic modulatory effect of cognitive and attentional set on the effective connectivity subtending the DMN: an effect that increases its sensitivity to inputs and may optimize distributed processing during task performance.
publisher	Frontiers Research Foundation
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381220/
_version_	1611538574317977600

Task-Dependent Modulation of Effective Connectivity within the Default Mode Network

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