Bromopyridazinedione-mediated protein and peptide bioconjugation† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc12807h Click here for additional data file.
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is reported. These bioconjugates exhibit excellent hydrolytic stability and cleave in an aqueous, thiol-mediated reducing environment.
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Royal Society of Chemistry
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379626/ |