Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses

Myxomatosis in Europe is the result of the release of a South America strain of myxoma virus in 1952. Several attenuated strains with origins in South America or California have since been used as vaccines in the rabbit industry. We sequenced the genome of the SG33 myxoma virus vaccine strain and co...

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Main Authors:	Camus-Bouclainville, Christelle, Gretillat, Magalie, Py, Robert, Gelfi, Jacqueline, Guérin, Jean-Luc, Bertagnoli, Stéphane
Format:	Online
Language:	English
Published:	Centers for Disease Control and Prevention 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377406/

id	pubmed-3377406
recordtype	oai_dc
spelling	pubmed-33774062012-06-20 Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses Camus-Bouclainville, Christelle Gretillat, Magalie Py, Robert Gelfi, Jacqueline Guérin, Jean-Luc Bertagnoli, Stéphane Research Myxomatosis in Europe is the result of the release of a South America strain of myxoma virus in 1952. Several attenuated strains with origins in South America or California have since been used as vaccines in the rabbit industry. We sequenced the genome of the SG33 myxoma virus vaccine strain and compared it with those of other myxoma virus strains. We show that SG33 genome carries a large deletion in its right end. Furthermore, our data strongly suggest that the virus isolate from which SG33 is derived results from an in vivo recombination between a wild-type South America (Lausanne) strain and a California MSD-derived strain. These findings raise questions about the use of insufficiently attenuated virus in vaccination. Centers for Disease Control and Prevention 2011-04 /pmc/articles/PMC3377406/ /pubmed/21470452 http://dx.doi.org/10.3201/eid1704.101146 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Camus-Bouclainville, Christelle Gretillat, Magalie Py, Robert Gelfi, Jacqueline Guérin, Jean-Luc Bertagnoli, Stéphane
spellingShingle	Camus-Bouclainville, Christelle Gretillat, Magalie Py, Robert Gelfi, Jacqueline Guérin, Jean-Luc Bertagnoli, Stéphane Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
author_facet	Camus-Bouclainville, Christelle Gretillat, Magalie Py, Robert Gelfi, Jacqueline Guérin, Jean-Luc Bertagnoli, Stéphane
author_sort	Camus-Bouclainville, Christelle
title	Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
title_short	Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
title_full	Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
title_fullStr	Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
title_full_unstemmed	Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses
title_sort	genome sequence of sg33 strain and recombination between wild-type and vaccine myxoma viruses
description	Myxomatosis in Europe is the result of the release of a South America strain of myxoma virus in 1952. Several attenuated strains with origins in South America or California have since been used as vaccines in the rabbit industry. We sequenced the genome of the SG33 myxoma virus vaccine strain and compared it with those of other myxoma virus strains. We show that SG33 genome carries a large deletion in its right end. Furthermore, our data strongly suggest that the virus isolate from which SG33 is derived results from an in vivo recombination between a wild-type South America (Lausanne) strain and a California MSD-derived strain. These findings raise questions about the use of insufficiently attenuated virus in vaccination.
publisher	Centers for Disease Control and Prevention
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377406/
_version_	1611537475673522176

Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses

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