HIV-1 replication activates CD4+ T cells with specificities for persistent herpes viruses

Hyperactivation of CD4+ T cells is a hallmark of untreated HIV-1 infection. The antigenic specificities of activated CD4+ T cells and the underlying mechanisms leading to their activation remain thus far elusive. We report here that during HIV rebound the dynamics of HIV-specific CD4+ T cells is hig...

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Bibliographic Details
Main Authors: Haas, Anna, Rehr, Manuela, Graw, Frederik, Rusert, Peter, Bossart, Walter, Kuster, Herbert, Trkola, Alexandra, Günthard, Huldrych F, Oxenius, Annette
Format: Online
Language:English
Published: WILEY-VCH Verlag 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377320/